Mechanism of Action

Extensive research has established that AUS_001 exerts broad and robust anti-cancer properties via its microtubule destabilizing effect promoting the induction of
i) G2/M cell cycle arrest
ii) mitochondrial dysfunction, impaired invasiveness and anchorage-independent growth
iii) aneuploidy
iv) programmed apoptotic death

In addition, the following findings provide additional impetus into the therapeutic potential of the drug candidate.

• Reversible mode of target engagement and increased uptake by cancer vs. normal cells
• In vitro studies prove a strong anti-cancer effect with a mechanism that involves anti-vascular disruption and immune response
• AUS_001 circumvents Pgp-mediated multidrug resistance
• 2D and 3D glioblastoma cultures with Temozolomide resistance retain sensitivity to the cytotoxic effects of AUS_001