Mechanism of Action

Extensive research has established several key processes involved in AUS_001’s mechanism of action which involves cytoskeleton interference and p53, AP-1, NF-kB, and DNA damage-response signaling pathways. In addition, the following findings provide additional impetus into the therapeutic potential of the drug candidate.

  • In vivo studies prove a strong anti-tumor effect with a mechanism that involves immune system and angiogenesis
  • Response profiling (using ex vivo tissue-patient derived 3D cell cultures) demonstrated superior potency against glioblastomas, especially relative to TMZ-resistant ones
  • Our results may accelerate patient selection (given BRAC2 mutated cells show increased sensitivity to our drug)
  • Our drug is not expected to lead to drug resistance in cancer cells
  • 5+ analogues in pipeline with similar characteristics
Terra Australis Pharmaceuticals PTY LTD is our operating and research affiliate headquartered in Adelaide, South Australia


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